| DAT | MOTSTÅNDARE | RESULTAT | målgörare | |
| 19 aug | H | WEST HAM | 4-2 | Hasselbaink 31 str, (Di Canio 48), Zola 60, Stanic 78, 88, (Kanoute 83) |
| 22 aug | b | Bradford | 0-2 |
(Windass 24, Carbone 74) |
| 28 aug | b | Aston Villa | 1-1 |
(Nilis 10), Desailly 30 |
| 6 sep | H | ARSENAL | 2-2 |
Hasselbaink 31, Zola 58 (Henry 76, Silvinho 86) |
| 9 sep | b | Newcastle | 0-0 |
- |
| 17 sep | H | LEICESTER | 0-2 |
(Izzett 8, Collymore 82) |
| 23 sep | b | Manchester United | 3-3 |
Hasselbaink 8, Flo 45, 70 (Scholes 14, Beckham 37, Sheringham 39) |
| 1 okt | H | LIVERPOOL | 3-0 | självmål 10, Hasselbaink 11, Gudjohnsen 71 |
| 6 okt | b | Sunderland | 0-1 |
(Phillips 63, straff) |
| 21 okt | H | COVENTRY | 6-1 | Hasselbaink 25 str, 42, 52, 58, Zola 48, Flo 68 (Roussel 89) |
| 28 okt | H | TOTTENHAM | 3-0 | Hasselbaink 13 str, 87, Zola 39 |
| 4 nov | b | Southampton | 2-3 |
Wise 69, Poyet 77 (Beattie 3, 90, Tessem 37) |
| 12 nov | H | LEEDS | 1-1 |
Poyet 79, (Viduka 62) |
| 18 nov | b | Charlton | 0-2 |
(Johansson 35, Pringle 90) |
| 25 nov | b | Everton | 1-2 |
Dalla Bona 45 (Cadamerteri 47, Campbell 71) |
| 3 dec | H | MANCHESTER CITY | 2-1 | Zola 26, Hasselbaink 45 (Dickov 82) |
| 9 dec | H | DERBY | 4-1 | Gudjohnsen 10, 16, Poyet 37, Zola 54 (Rigott 56) |
| 16 dec | b | Middlesbrough | 1-0 | (Gordon 71) |
| 23 dec | H | BRADFORD | 3-0 | Poyet 22, Dalla Bona 65, Gudjohnsen 90 |
| 26 dec | b | Ipswich | 2-2 |
Gudjohnsen, 8, 17 (Showcroft 43, Stewart 82) |
| 2001 1 jan |
H | ASTON VILLA | 1-0 | Hasselbaink 45 |
| 13 jan | b | Arsenal | 1-1 |
(Pires 3) Terry 62 |
| 20 jan | H | IPSWICH | 4-1 | (Stewart 20), Poyet 45, 65, Wise 58, Hasselbaink 73 str |
| 31 jan | H | NEWCASTLE | 3-1 | (Bassedas 23) Zola 37, Poyet 62, Grønkjaer 76 |
| 3 feb | b | Leicester | 1-2 |
(Izzett 24, Rowett 76) Hasselbaink 75 |
| 10 feb | H | MANCHESTER UNITED | 1-1 |
Hasselbaink 24 (Cole 69) |
| 3 mars | b | Coventry | 0-0 |
- |
| 7 mars | b | West Ham | 2-0 | Gudjohnsen 32, Hasselbaink 38 |
| 17 mars | H | SUNDERLAND | 2-4 |
Desailly 14, Gudjohnsen 37 (Hutchison 28, 52 McGann 61, Phillips 80) |
| 31 mars | H | MIDDLESBROUGH | 2-1 | Zola 35, Gudjohnsen 63 (Windass 54) |
| 7 april | b | Derby | 4-0 | Zola 64, Hasselbaink 85, Poyet 90, 90 |
| 14 april | H | SOUTHAMPTON | 1-0 | Poyet 41 |
| 17 april | b | Tottenham | 3-0 | Hasselbaink 29, Poyet 60, Gudjohnsen 90 |
| 21 april | H | CHARLTON | 0-1 |
(Bartlett 35) |
| 28 april | b | Leeds | 0-2 |
(Keane 85, Viduka 88) |
| 5 maj | H | EVERTON | 2-1 | (Campbell 3) Hasselbaink 32, 34 |
| 8 maj | b | Liverpool | 2-2 |
(Owen 7, 60) Hasselbaink 13, 66 |
| 19 maj | b | Manchester City | 2-1 | Wise 16, Hasselbaink 62 (Howey 39) |